May 1, 2023 Puzzle Piece
Quercetin shown to improve Covid-19 recovery in new study
Quercetin may be the latest nutrient to offer hope in reducing the symptoms of Covid-19.
In a test of Covid-19 patients in Pakistan, a one-week treatment with
quercetin was linked to milder symptoms and faster conversion from
positive to negative tests.
Quercetin is a plant flavonol from the flavonoid group of
polyphenols. It is found in many fruits, vegetables, leaves, seeds, and
grains. Quercetin has a bitter flavor; however, it is still used as an
additive to some foods and beverages.
Though quercetin is one of the most abundant dietary flavonoids found
organically in nature, processing and heating eliminates much of the
amount typically found in raw foods.
Substantial earlier research has demonstrated that quercetin provides
broad-spectrum antiviral, anti-inflammatory and antioxidant properties.
A 2003 study found quercetin possessed the ability to stablize cells,
and a 2010 study found quercetin had an immunosuppressive effect on cell
function.
Researchers in the current study noted quercetin’s long-proven benefits
and acknowledged preliminary studies that had already linked the
nutrient to Covid-19 benefits.
“Recently, several clinical trials have revealed treatment benefits of
quercetin supplementation in patients with COVID-19, including
prophylaxis, speedy clearance of the SARS-CoV-2, speedy resolution of
the acute symptoms and improvement in the serum inflammatory biomarker
levels,” the researchers wrote in the study introduction.
Study details
To conduct the study 100
Covid-19 patient-subjects were randomized to receive either a placebo
or a quercetin supplement at the onset of testing positive for Covid-19.
The quercetin product was supplied by a known supplement manufacturer
and was tested for purity before administration. Both the supplement
group and the placebo group also received the same “standard Covid-19
care” that is provided to patients in Pakistan. The study was reserved
to patients with “moderate” Covid symptoms.
According to an array of tests from outpatient physicians, “Quercetin
use resulted in milder COVID-19 symptoms and improved the rate of
testing positive to testing negative.”
After one week of treatment, 34 patients tested negative for Covid-19,
compared to 12 in the control group. Twenty-six patients, compared to 12
in the control group, had their Covid-19 associated acute symptoms
resolved.
Quercetin supplementation was also significantly linked to a faster
reduction in serum LDH, a biomarker which suggests systemic
inflammation.
“Our results, suggest the possible therapeutic role of quercetin in
early-stage COVID-19, including speedy clearance of SARS-CoV-2, early
resolution of the acute symptoms and modulation of the host’s
hyperinflammatory response,” the researchers wrote in the study
conclusion.
The study was an open-label randomized controlled clinical trial, and was conducted at the department of medicine, King Edward Medical University, Lahore, Pakistan.
The study was registered at the U.S. National Library of Medicine’s ClinicalTrials.gov, and the results were published in Frontiers in Pharmacology in January 2023.
While noting larger studies are needed, the authors concluded that there
is a possible therapeutic role of quercetin supplementation in the
early stages of mild to moderate symptomatic Covid-19.
“The present study also supports the safety of quercetin supplementation
in patients with COVID-19 which has an unpredictable and complex course
and hence may be used as an adjuvant alongside routine care in the
management of mild to moderate symptoms of COVID-19,” the researchers
wrote in the study summary.
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Sourcess: Frontiers in Pharmacology, Biocell, Journal of Immunology.
Yours in Health and Wellness,
OHS and John W Brimhall, DC, BA, BS, FIAMA, DIBAK
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