This week’s Puzzle Piece comes from Labrix Clinical Services
The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are crucial for healthy neurotransmitter production and nervous system function. EPA is a potent anti-inflammatory, while DHA contributes to the fluidity of cell membranes. Omega-3 fatty acids are called "essential" fats for good reason; our bodies cannot make them, so we must get them from outside sources. EPA and DHA are found directly in fatty fish like salmon, and shorter chain omega-3 fatty acids such as alpha-linoleic acid (ALA) are found in flaxseeds and walnuts, however the body must convert them into EPA and DHA for maximum benefit. Because these foods are not typically eaten in large amounts in North America, omega 3 supplementation has become an important source of these nutrients.
Omega-3 fatty acids are so important to the development and proper maintenance of the brain that some scientists have proposed that it was the ingestion of omega-3 EFAs that allowed the brain to evolve to the next stage in human development.
DHA plays a vital role in the structure and function of the brain and is a significant component of nerve cells and myelin. DHA's effects may be due, in part, to its effect on increasing the fluidity of cell membranes, which improves their ability to release neurotransmitters, but it may also improve cell signaling. DHA has shown to exert complex effects on the secretion of a number of neurotransmitters, including serotonin, norepinephrine, acetylcholine, glutamate and dopamine. Additionally, DHA plays a key role in neurotransmitter receptor function.
EPA is more involved with modulating the effects of inflammation in the brain. Unlike acute brain inflammation, as seen with meningitis and encephalitis, chronic brain inflammation can be silent except for its behavioral manifestations. Chronic brain inflammation can be the result of a number of conditions, such as abdominal obesity, latent viral infections, autoimmune diseases, metabolic syndrome, and deficiencies in omega-3 oils. Studies have revealed a close correlation between chronic inflammation and depression. It may be that omega-3 oils improve depression and other disorders by reducing brain inflammation.
Testing neurotransmitter levels often reveals imbalance in our patients. While targeted amino acid and cofactor supplementation are recommended to address specific imbalances, omega-3 fatty acid supplementation may be an important addition to any treatment plan.
References:
* Chalon S, et al. Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. J Nutr. 1998 Dec;128(12):2512-9
* Chamberlain JG. The possible role of long-chain, omega-3 fatty acids in human brain phylogeny. Perspect Biol Med. 1996 Spring;39(3):436-45.
* De la Presa OS, et al. Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotranmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula fed piglets. J Nutr. 1999 Nov; 129(11):2088-93.
* Kiecolt-Glaser JK, et al. Depressive symptoms, omega-6: omega 3 fatty acids, and inflammation in older adults. Psychosom Med. 2007 Apr; 69(3):217-24.
* Kitajka K, et al. The role of omega-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary omega-3 fatty acids. Proc Natl Acad Sci USA, 2002 Mar 5;99(5):2619-24
* Litman BJ, et al. The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways: visual transduction. J Mol Neurosci. 2001 Apr;16(2-3):237-42
THANKS TO JAY MEAD, MD AND LABRIX FOR THIS WEEKS PUZZLE PIECE AND GREAT SCIENCE.
My favorite Omega 3 is LipiChol from XYMOGEN. Dr Brett, Brandy and I take it daily. It is from krill oil and has the best track record for all of the good effects mentioned in this article.
XYMOGEN also has the OmegaPure Fish Oils from 300 to 900 mg. I always evaluate for MaX Brain also that helps to balance neurotransmitters and allow for proper brain function. Whether looking for proper brain function or weight balance, we evaluate for toxic halides and/or heavy metals. We use the homeopathic homocords of these substances such as MaX Lead, MaX Fluorine etc. to help in detoxification and assists in normalization of function.
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